befiradol

  • CasNo：208110-64-9
  • purity：99%
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Details

Factory supply befiradol 208110-64-9 with sufficient stock and high standard

  • Molecular Formula: C20H22 Cl F2 N3 O
  • Molecular Weight: 393.864
  • Boiling Point: 536.9±50.0 °C(Predicted) 
  • PKA: 8.01±0.20(Predicted) 
  • PSA： 45.23000 
  • Density: 1.30 
  • LogP: 4.24540 

208110-64-9 Relevant articles

Conformational analysis and crystal structure of {[1-(3-chloro-4- fluorobenzoyl)-4-fluoropiperidin-4yl]methyl}[(5-methylpyridin-2-yl)methyl]amine, fumaric acid salt

Ribet,Pena,Maurel,Belin,Tillard,Vacher,Bonnaud,Colpaert

, p. 353 - 363 (2005)

{[1-(3-Chloro-4-fluorobenzoyl)-4-fluorop...

Deuterium-Substituted Pyridin- And Pyrimidin-2-yl-Methylamine Compounds

-

Paragraph 0305; 0318; 0319; 0320, (2018/04/14)

Described are deuterium-substituted pyri...

Novel pyridylmethylamines as highly selective 5-HT1A superagonists

Bollinger, Stefan,Hübner, Harald,Heinemann, Frank W.,Meyer, Karsten,Gmeiner, Peter

supporting information; experimental part, p. 7167 - 7179 (2010/12/19)

To further improve the maximal serotoner...

Synthesis method and intermediates of pyridin-2-yl-methylamine

-

Page 5, (2008/06/13)

The invention concerns a novel method fo...

208110-64-9 Process route

2-[1-[(3-chloro-4-fluorophenyl)carbonyl]-4-fluoropiperidin-4-yl]-2-hydroxyacetonitrile
448920-98-7

2-[1-[(3-chloro-4-fluorophenyl)carbonyl]-4-fluoropiperidin-4-yl]-2-hydroxyacetonitrile

1,4-diaza-bicyclo[2.2.2]octane
280-57-9,88935-43-7

1,4-diaza-bicyclo[2.2.2]octane

(5-methylpyridin-2-yl)methylamine (dihydrochloride)
161647-06-9

(5-methylpyridin-2-yl)methylamine (dihydrochloride)

(3-chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone
208110-64-9

(3-chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone

Conditions
Conditions Yield
With sodium cyanoborohydride; In methanol; at 20 ℃; for 4h;
78%
2-[1-[(3-chloro-4-fluorophenyl)carbonyl]-4-fluoropiperidin-4-yl]-2-hydroxyacetonitrile
448920-98-7

2-[1-[(3-chloro-4-fluorophenyl)carbonyl]-4-fluoropiperidin-4-yl]-2-hydroxyacetonitrile

[5-methylpyridin-2-yl]methanamine hydrochloride
161647-06-9

[5-methylpyridin-2-yl]methanamine hydrochloride

(3-chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone
208110-64-9

(3-chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone

Conditions
Conditions Yield
With 1,4-diaza-bicyclo[2.2.2]octane; sodium cyanoborohydride; In methanol; at 25 ℃;
120 mg

208110-64-9 Upstream products

  • 448920-98-7
    448920-98-7

    2-[1-[(3-chloro-4-fluorophenyl)carbonyl]-4-fluoropiperidin-4-yl]-2-hydroxyacetonitrile

  • 45715-08-0
    45715-08-0

    ((5-methyl-pyridin-2-yl)-methyl)-amine

  • 448920-97-6
    448920-97-6

    6-[(3-chloro-4-fluorophenyl)carbonyl]-1-oxa-6-azaspiro[2.5]octane-2-carbonitrile

  • 177-11-7
    177-11-7

    4,4-ethylenedioxy-piperidine

208110-64-9 Downstream products

  • 1256167-79-9
    1256167-79-9

    N-[1-(3-chloro-4-fluorobenzoyl)-4-fluoropiperidin-4-yl]methyl-N-methyl-N-(5-methylpyridin-2-yl)methylamine

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