SCH772984

Good factory supply good SCH772984 942183-80-4 We provide high quality SCH772984 (CAS 942183-80-4), at a very affordable prices to our customers.

1.What is the SCH772984 ?

The extracellular regulated kinases 1 and 2 (ERK1/2) are functionally redundant kinases activated by a variety of growth factors and mitogens. SCH 772984 is a potent inhibitor of ERK1 and ERK2 (IC50s = 4 and 1 nM, respectively). It is highly selective, with only seven kinases of 300 tested showing more than 50% inhibition at a concentration of 1 μM. SCH 772984 has nanomolar cytotoxicity in tumor cells with mutations in BRAF, NRAS, or KRAS. It is effective in vivo, inducing regression of xenograft tumors in mice. SCH 772984 displays slow binding kinetics, binding to a novel binding pocket in inactive ERK isoforms.

SCH772984 is a novel and selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors and has nanomolar cellular potency in tumor cells with mutations in BRAF, NRA5, or KRAS and induces tumor regressions in xenograft models.

2.What is the CAS number for SCH772984 ?

The CAS number of SCH772984 is 942183-80-4.

More information of SCH772984 942183-80-4 are:

3.What is the molecular formula of SCH772984 ?

The chemical formula of?SCH772984 is C33H33N9O2 which containing 33 Carbon atoms,33 Hydrogen atoms,9 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight, and the molecular weight of SCH772984 is 587.67

4.What is SCH772984(942183-80-4)used for?

The extracellular regulated kinases 1 and 2 (ERK1/2) are functionally redundant kinases activated by a variety of growth factors and mitogens. SCH 772984 is a potent inhibitor of ERK1 and ERK2 (IC50s = 4 and 1 nM, respectively). It is highly selective, with only seven kinases of 300 tested showing more than 50% inhibition at a concentration of 1 μM. SCH 772984 has nanomolar cytotoxicity in tumor cells with mutations in BRAF, NRAS, or KRAS. It is effective in vivo, inducing regression of xenograft tumors in mice. SCH 772984 displays slow binding kinetics, binding to a novel binding pocket in inactive ERK isoforms.

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5.Good factory supply good SCH772984 942183-80-4

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