Details
Quality manufacturer supply (1S-cis)-4-Amino-2-cyclopentene-1-methanol 136522-35-5 in stock with high standard
- Molecular Formula:C6H11NO
- Molecular Weight:113.159
- Vapor Pressure:0.068mmHg at 25°C
- Refractive Index:1.512
- Boiling Point:203.326 °C at 760 mmHg
- PKA:14.86±0.10(Predicted)
- Flash Point:76.769 °C
- PSA：46.25000
- Density:1.046 g/cm3
- LogP:0.58240
(1S-cis)-4-Amino-2-cyclopentene-1-methanol(Cas 136522-35-5) Usage
InChI:InChI=1/C6H11NO/c7-6-2-1-5(3-6)4-8/h1-2,5-6,8H,3-4,7H2/t5-,6+/m1/s1
136522-35-5 Relevant articles
Synthesis of novel N-cyclopentenyl-lactams using the Aubé reaction
Shinde, Madhuri V.,Ople, Rohini S.,Sangtani, Ekta,Gonnade, Rajesh,Reddy, D. Srinivasa
supporting information, p. 1060 - 1067 (2015/08/18)
A novel and convenient method utilizing ...
Acetoxy Meldrum's acid: A versatile acyl anion equivalent in the Pd-catalyzed asymmetric allylic alkylation
Trost, Barry M.,Osipov, Maksim,Kaib, Philip S. J.,Sorum, Mark T.
supporting information; experimental part, p. 3222 - 3225 (2011/08/07)
Acetoxy Meldrum's acid can serve as a ve...
Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca2+-mobilizing second messenger. Structure-activity relationship of the N1-ribose moiety
Kudoh, Takashi,Fukuoka, Masayoshi,Ichikawa, Satoshi,Murayama, Takashi,Ogawa, Yasuo,Hashii, Minako,Higashida, Haruhiro,Kunerth, Svenja,Weber, Karin,Guse, Andreas H.,Potter, Barry V. L.,Matsuda, Akira,Shuto, Satoshi
, p. 8846 - 8855 (2007/10/03)
We previously developed cyclic ADP-carbo...
Process for the synthesis of chloropurine intermediates
-
Page/Page column 4-5, (2010/11/30)
The present invention relates to a proce...
136522-35-5 Process route
-
-
25125-21-7
4-(hydroxymethyl)cyclopentene
-
-
121481-90-1,122624-72-0,131320-53-1,136522-30-0,136522-35-5
(+/-)-cis-(4-hydroxymethyl)cyclopent-2-en-1-ylamine
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 8 steps
1: 82 percent / pyridine / 0 - 20 °C
2: m-CPBA / CH2Cl2 / -78 - 0 °C
3: 98 percent / LiN3, (NH4)SO4 / ethanol; H2O / Heating
4: 76 percent / Et3N / CH2Cl2
5: 34 percent / DBU / tetrahydrofuran / Heating
6: 1,3-propanedithiol, Et3N
7: pyridine
8: Ba(OH)2 / H2O / Heating
With
pyridine; 1.3-propanedithiol; barium dihydroxide; lithium azide; (NH4)SO4; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; ethanol; dichloromethane; water;
|
-
-
(-)-(1S, 4R)-4-amino-2-cyclopentene-1-carboxylic acid methanesulfonate
-
-
136522-35-5
(1R,4S)-1-amino-4-hydroxymethyl-2-cyclopentene
| Conditions | Yield |
|---|---|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 19.5h;
Heating;
|
90.5% |
|
With
sodium fluoride;
In
tetrahydrofuran; methanol; water-tetrahydrofuran; diethyl ether; water;
|
90.5% |
|
With
sodium fluoride;
In
tetrahydrofuran; methanol; water-tetrahydrofuran; diethyl ether; water;
|
90.5% |
|
(-)-(1S, 4R)-4-amino-2-cyclopentene-1-carboxylic acid methanesulfonate;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 10 ℃;
for 19.5h;
Heating / reflux;
With
sodium fluoride;
In
diethyl ether; water;
at 5 ℃;
for 3h;
|
90.5% |
136522-35-5 Upstream products
-
132243-27-7
cis-4-hydroxymethyl-1-ureidocyclopent-2-ene
-
172720-97-7
(+/-)-tert-butyl (1RS,4SR)-4-(hydroxymethyl)cyclopent-2-enylcarbamate
-
49805-30-3
racemic 2-azabicyclo[2.2.1]hept-5-en-3-one
-
49805-30-3
2-azabicyclo[2.2.1.]hept-5-en-3-one
136522-35-5 Downstream products
-
172720-97-7
(+/-)-tert-butyl (1RS,4SR)-4-(hydroxymethyl)cyclopent-2-enylcarbamate
-
141271-13-8
(1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol
-
136522-33-3
(1S,4R)-4-[2-amino-6-chloro-9H-purin-9-yl]-2-cyclopentene-1-methanol
-
69971-20-6
(-)-(1S,4R) acetic acid 4-acetylamido-cyclopent-2-enyl-methyl ester
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