Details
Manufacturer supply 2-Acetyl-4-methylpyridine 59576-26-0 with sufficient stock and high standard
- Molecular Formula:C8H9NO
- Molecular Weight:135.166
- Vapor Pressure:0.0788mmHg at 25°C
- Melting Point:30-34 °C(lit.)
- Refractive Index:1.512
- Boiling Point:227.1 °C at 760 mmHg
- PKA:3.82±0.10(Predicted)
- Flash Point:96.5 °C
- PSA：29.96000
- Density:1.036 g/cm3
- LogP:1.59260
2-Acetyl-4-methylpyridine(Cas 59576-26-0) Usage
|
General Description |
2-Acetyl-4-methylpyridine is a substituted pyridine that can be prepared from 2-bromo-4-methylpyridine. |
InChI:InChI=1/C8H9NO/c1-6-3-4-9-8(5-6)7(2)10/h3-5H,1-2H3
59576-26-0 Relevant articles
NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF
-
Paragraph 0943; 1195; 1198-1200, (2016/07/05)
There is provided a morpholine derivativ...
Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones
Fosso, Marina Y.,LeVine, Harry,Green, Keith D.,Tsodikov, Oleg V.,Garneau-Tsodikova, Sylvie
supporting information, p. 9418 - 9426 (2015/09/15)
As the number of individuals affected wi...
Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure-activity relationship for anti-inflammatory drug
Hayashi, Shigeo,Ueno, Naomi,Murase, Akio,Nakagawa, Yoko,Takada, Junji
experimental part, p. 179 - 195 (2012/07/27)
Cyclooxygenase (COX) is a key rate-limit...
PYRAZOLE DERIVATIVE
-
Page/Page column 58, (2010/11/27)
A compound represented by Formula (I): w...
59576-26-0 Process route
-
-
1620-76-4
2-Cyano-4-methylpyridin
-
-
917-64-6
methyl magnesium iodide
-
-
59576-26-0
2-acetyl-4-methylpyridine
| Conditions | Yield |
|---|---|
|
2-Cyano-4-methylpyridin; methyl magnesium iodide;
In
diethyl ether; benzene;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
With
water; ammonium chloride;
In
diethyl ether; benzene;
Inert atmosphere;
|
52% |
|
With
diethyl ether; benzene;
Behandeln des Reaktionsgemisches mit wss.Ammoniumchlorid-Loesung;
|
-
-
4926-28-7
2-Bromo-4-picoline
-
-
127-19-5,116057-81-9
N,N-dimethyl acetamide
-
-
59576-26-0
2-acetyl-4-methylpyridine
| Conditions | Yield |
|---|---|
|
2-Bromo-4-picoline;
With
n-butyllithium;
In
diethyl ether; hexane;
at -78 ℃;
for 0.166667 - 0.5h;
N,N-dimethyl acetamide;
In
diethyl ether; hexane;
at 20 ℃;
for 2 - 14.5h;
Product distribution / selectivity;
|
59% |
|
2-Bromo-4-picoline;
With
n-butyllithium;
In
diethyl ether; hexane;
at -78 ℃;
for 0.166667h;
N,N-dimethyl acetamide;
In
diethyl ether; hexane;
at 20 ℃;
for 14.5h;
|
59% |
|
With
n-butyllithium;
In
diethyl ether; hexane;
|
37% |
59576-26-0 Upstream products
-
1620-76-4
2-Cyano-4-methylpyridin
-
917-64-6
methyl magnesium iodide
-
4926-28-7
2-Bromo-4-picoline
-
127-19-5
N,N-dimethyl acetamide
59576-26-0 Downstream products
-
204701-34-8
1-{3-oxo-3-[2-(4-methylpyridyl)]propen-1-yl}-4-chlorobenzene
-
878007-29-5
1-(3-oxo-3-[2-(4-methylpyridyl)]propen-1-yl)-4-bromobenzene
-
108295-43-8
4-(2-((p-tolylsulfonyl)oxy)ethyl)-2,2':6',2''-terpyridinyl
-
1134-35-6
4,4'-dimethyl-2,2'-bipyridines
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